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The primary goals in the Goldstein lab are to unravel how molecular motors interact with, and control the behavior of, axonal vesicles, and to relate this understanding to the molecular basis of neuronal defects in Alzheimer's Disease (AD) and Niemann Pick type C disease.
We are taking advantage of pluripotent stem cell lines that contain known mutations that cause hereditary Alzheimer's disease, as well as Niemann Pick Type C disease. This latter disease is of interest because it directly ties cholesterol trafficking and transport to what appears to be a pediatric form of Alzheimer type dementia.
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Stem cell reportsno. 12 (2023): 2300-2312
Cell stem cellno. 9 (2021): 1533-1548.e6
Lawrence S. B. Goldstein, Robert N. Klein
Scienceno. 6526 (2021): 215-+
Rodrigo S Chaves, My Tran, Andrew R Holder, Alexandra M Balcer,Andrea M Dickey,Elizabeth A Roberts,Brian G Bober,Edgar Gutierrez,Brian P Head,Alex Groisman,Lawrence S B Goldstein,Angels Almenar-Queralt,
Progress in molecular biology and translational science (2020): 109-122
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