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Dr. Lash’s research program over the past nearly four decades has focused on various aspects of determining how chemicals produce injury to the kidneys and how we can design approaches to preventing or correcting such injury. The experimental models have included in vivo studies in rats and mice and in vitro studies using established cell lines and freshly isolated tissue and primary cell culture from rodent and human kidney. The chemicals used to produce kidney toxicity fall into one of three categories: 1) Model chemicals that are used to study specific mechanisms of action; 2) pharmacologic agents whose clinical use is dose-limited by nephrotoxicity, such as analgesics, antibiotics, and antiviral agents; and 3) environmental chemicals, such as inorganic mercury and tri- and perchloroethylene. We have also explored the impact of chronic diseases (e.g., diabetes) and pathological states (e.g., reduced nephron mass with compensatory renal hypertrophy or hypoxia) on susceptibility of the kidneys to chemically induced toxicity.
研究兴趣
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TOXICOLOGICAL SCIENCESno. 2 (2024): 211-221
ASPET 2024 Annual Meeting Abstract - Toxicology (2024)
Biochemical Pharmacologypp.116181-116181, (2024)
Toxicological sciences : an official journal of the Society of Toxicology (2023)
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
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CRC Press eBookspp.145-163, (2023)
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The Journal of pharmacology and experimental therapeuticsno. 2 (2023): 131-134
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