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My lab is currently pursuing several projects:
1. The role of TIM-3 in T cells and mast cells
This project currently involves the study of - TIM-3, a novel protein of the T cell immunoglobulin and mucin domain family in regulation of T cell and mast cell function. Previous studies have suggested that TIM-3 has different effects on these two cell types, i.e. down-regulation of Th1 T cell function and upregulation of myeloid cell function. Among other things, they are interested in elucidating signaling pathways downstream of TIM-3 in these two cell types.
2. Regulation of T cell and mast cell activation by PIK3IP1/TrIP, a novel regulator of PI3K
Dr. Kane's lab has found that a novel transmembrane protein known as PIK3IP1 (PI3K-interacting protein 1) or TrIP (transmembrane inhibitor of PI3K) is expressed in both T cells and mast cells. This protein appears to restrict early activation of both cell types. The lab is currently characterizing mice with inducible deletion of TrIP to better understand how this protein functions in vivo.
3. Regulation of mTOR activation by Carma1 and MALT1
Dr. Kane and his lab recently elucidated a previously unappreciated connection between the proteins Carma1 and MALT1 and the mTOR pathway, the latter of which was thought to be controlled solely by a PI3K/Akt dependent mechanism. His lab is now working to further define this pathway and its consequences for T cell activation and differentiation.
1. The role of TIM-3 in T cells and mast cells
This project currently involves the study of - TIM-3, a novel protein of the T cell immunoglobulin and mucin domain family in regulation of T cell and mast cell function. Previous studies have suggested that TIM-3 has different effects on these two cell types, i.e. down-regulation of Th1 T cell function and upregulation of myeloid cell function. Among other things, they are interested in elucidating signaling pathways downstream of TIM-3 in these two cell types.
2. Regulation of T cell and mast cell activation by PIK3IP1/TrIP, a novel regulator of PI3K
Dr. Kane's lab has found that a novel transmembrane protein known as PIK3IP1 (PI3K-interacting protein 1) or TrIP (transmembrane inhibitor of PI3K) is expressed in both T cells and mast cells. This protein appears to restrict early activation of both cell types. The lab is currently characterizing mice with inducible deletion of TrIP to better understand how this protein functions in vivo.
3. Regulation of mTOR activation by Carma1 and MALT1
Dr. Kane and his lab recently elucidated a previously unappreciated connection between the proteins Carma1 and MALT1 and the mTOR pathway, the latter of which was thought to be controlled solely by a PI3K/Akt dependent mechanism. His lab is now working to further define this pathway and its consequences for T cell activation and differentiation.
研究兴趣
论文共 191 篇作者统计合作学者相似作者
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Benjamin M Murter, Sean C Robinson,Hridesh Banerjee, Louis Lau,Uzodinma Uche,Andrea L Szymczak-Workman,Lawrence P Kane
bioRxiv : the preprint server for biology (2024)
Journal of immunology (Baltimore, Md. : 1950)no. 3 (2024): 466-474
Benjamin M. Murter, Sean C. Robinson,Hridesh Banerjee, Louis Lau,Uzodinma Uche,Andrea L. Szymczak-Workman,Lawrence P. Kane
crossref(2024)
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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Angela M. M. Gocher-Demske,Jian Cui,Andrea L. L. Szymczak-Workman,Kate M. M. Vignali,Julianna N. N. Latini,Gwen P. P. Pieklo, Jesse C. C. Kimball,Lyndsay Avery,Ellyse M. M. Cipolla,Brydie R. R. Huckestein,Lee Hedden,Marlies Meisel,
Nature immunologyno. 5 (2023): 841-+
BLOOD ADVANCESno. 22 (2023): 6949-6963
Regular and Young Investigator Award Abstracts (2023)
Timothy R. McCulloch,Gustavo Rodrigues Rossi, Allie Lam, Joshua Wong,Lawrence P. Kane,Marco Herold,Timothy Wells, Fernando Souza-Fonseca-Guimaraes
Journal of Immunologyno. 1 (2023): 72.28-72.28
Angela M. Gocher-Demske,Jian Cui,Andrea L. Szymczak-Workman,Kate M. Vignali, Julianna N. Latini, Gwen P. Pieklo, Jesse C. Kimball,Lyndsay Avery,Ellyse M. Cipolla,Brydie R. Huckestein,Lee Hedden,Marlies Meisel,
Nature Immunologyno. 5 (2023): 841-854
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