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Dr. Chan's laboratory is active in the following research areas: 1) Type 1 and type 2 diabetes and the metabolic syndrome, molecular biology and pathogenesis and 2) Somatic gene therapy and other molecular therapies for the treatment of diabetes and obesity.
Dr. Chan is interested in the molecular pathology of hyperglycemia and diabetic complications. Dr. Chan and his colleagues first described the appearance of insulin-producing cells in multiple extrapancreatic tissues in diabetes. The laboratory showed that the insulin-producing cells are derived from bone marrow cells that migrate from the bone marrow to multiple tissues, including the liver and adipose tissues. They may retain their bone marrow cell characteristics or they may fuse with the local cells in various tissues and organs. His laboratory further showed that the fusion of these abnormal bone marrow-derived cells with nerve cells is an important factor in diabetic neuropathy.
Dr. Chan is interested in the molecular pathology of hyperglycemia and diabetic complications. Dr. Chan and his colleagues first described the appearance of insulin-producing cells in multiple extrapancreatic tissues in diabetes. The laboratory showed that the insulin-producing cells are derived from bone marrow cells that migrate from the bone marrow to multiple tissues, including the liver and adipose tissues. They may retain their bone marrow cell characteristics or they may fuse with the local cells in various tissues and organs. His laboratory further showed that the fusion of these abnormal bone marrow-derived cells with nerve cells is an important factor in diabetic neuropathy.
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Cornea Openno. 1 (2023): e0010-e0010
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Emmanuel Uchenna Agu,Arman Mosenia, Jacob A. Lifton,Lawrence Chan, Katherine G. Ligtenberg,Drew Saylor,Reza Vagefi,Seanna R. Grob,Robert Kersten, Melena Ahmad,Bryan Winn
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