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Dr. Hurley’s present research interests are in the areas of design and development of antitumor agents. Over the last forty years, work from his laboratory has led to elucidation of the structures of the drug–nucleic acid complexes for seven different groups of compounds that are potentially useful in the treatment of cancer. In cooperation with the pharmaceutical industry, several drugs developed with the aid of these studies have been evaluated in phase 1 and 2 clinical trials. Most recently his research has centered on secondary DNA structures, particularly G-quadruplexes and C-quadruplexes (also called i-motifs), as gene targets for drug design. While he was CSO of Cylene Pharmaceuticals a first-in-class G-quadruplex-interactive compound (Quarfloxin), developed from this technology and licensed from the University of Arizona, was advanced into phase 1 and 2 clinical trials in 2007.
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