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个人简介
Laurance David Hall was born in Wapping, London on 18th March 1938. Like so many London
children, he was evacuated to the country to escape the bombing during the War. He was
educated at the University of Bristol (1st Class B.Sc. Honours in Chemistry), where he earned a
Ph.D. (1962) in carbohydrate chemistry under the supervision of Les Hough. He then travelled
to Canada for a post-doctoral fellowship with Frank Anet at the University of Ottawa (1962-63).
In 1963, he joined the Faculty of the Department of Chemistry, University of British Columbia
(UBC), Vancouver. While working on his Ph.D. he had realized the potential of the then
relatively new technique of nuclear magnetic resonance (NMR) spectroscopy for solving
problems of the structure and stereochemistry of carbohydrates and other organic compounds.
At UBC he set up a very active carbohydrate research group for which NMR spectroscopy was a
primary tool. His group studied such topics as halogenation of carbohydrates, structures of
fluorinated sugars, properties of glycoproteins, functionalized carbohydrates, e.g. with spin
labels, motion of carbohydrates in solution and use of spin-labels as motional probes, and
stereochemical dependence of 1
H-19F coupling constants in sugars. 1
H, 13C and 19F NMR
spectroscopy were used for structure determination. He saw how proton spin-lattice relaxation
rates could provide spatial information, and became very active in this area when a pulse/Fourier
transform NMR spectrometer was installed.
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