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Our research focuses on a class of proteins with very distinctive architectures, known as tandem-repeat proteins. Our group and others have shown that the simple modular, one-dimensional architecture of tandem-repeat proteins gives them distinctive properties that make it uniquely straightforward to map the energetics of their structures and to rationally redesign their stability, folding and binding function.
This class of proteins is thus an exceptionally sensitive and versatile tool that we are now exploiting to dissect otherwise intractable cellular mechanisms. We are also exploring how to exploit the extraordinary design-ability of these proteins for biomedical and biotechnology applications.
Our research focuses on a class of proteins with very distinctive architectures, known as tandem-repeat proteins. Our group and others have shown that the simple modular, one-dimensional architecture of tandem-repeat proteins gives them distinctive properties that make it uniquely straightforward to map the energetics of their structures and to rationally redesign their stability, folding and binding function.
This class of proteins is thus an exceptionally sensitive and versatile tool that we are now exploiting to dissect otherwise intractable cellular mechanisms. We are also exploring how to exploit the extraordinary design-ability of these proteins for biomedical and biotechnology applications.
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crossref(2024)
Mia Kapun,F. Javier Perez-Areales, Nicola Ashman,Pamela J. E. Rowling, Tim Schober,Elaine Fowler,Laura S. Itzhaki,David R. Spring
RSC CHEMICAL BIOLOGYno. 1 (2024): 49-54
Harry R King,Mark Bycroft,Thanh-Binh Nguyen,Geoff Kelly, Alexander A Vinogradov, Pamela JE Rowling,Katherine Stott,David B Ascher,Hiroaki Suga,Laura Susan Itzhaki,Katerina Artavanis-Tsakonas
biorxiv(2024)
Mateo P Hoare, Daniel Mcilwaine, Tin Long Chris Ng,Luisa Capalbo, Ellis J Wilde,Laura S Itzhaki,Janet R Kumita
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSno. SUPPL 1 (2023): S44-S44
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Tin Long Chris Ng,Mateo Hoare,Timothy Welsh,Sneideris Tomas, Ellis Wilde,Tuomas P J Knowles,Laura S Itzhaki,Janet R Kumita
PROTEIN SCIENCE (2023)
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PROTEIN SCIENCE (2023)
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