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Walker's early research established that a variety of neurons are involved in the formation of Aβ plaques, one of the pathological hallmarks of Alzheimer's disease. With Dale Schenk at Athena Neurosciences (later part of Élan Pharmaceuticals), he discovered that antibodies to the Aβ protein can enter the brain from the cerebrospinal fluid and selectively bind to Aβ plaques and cerebral Aβ-amyloid angiopathy (CAA). Based on his work with animal models of Alzheimer's disease, Walker has proposed that humans are uniquely vulnerable to Alzheimer's disease.
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Nature Medicineno. 2 (2024): 344-345
Christine Rother,Ruth E. Uhlmann,Stephan A. Müller,Juliane Schelle,Angelos Skodras,Ulrike Obermüller,Lisa M. Häsler,Marius Lambert,Frank Baumann, Ying Xu,Carina Bergmann, Giulia Salvadori,
Jessica Wagner,Karoline Degenhardt, Marleen Veit,Nikolaos Louros,Katerina Konstantoulea,Angelos Skodras, Katleen Wild,Ping Liu,Ulrike Obermüller,Vikas Bansal, Anupriya Dalmia,Lisa M. Häsler,
Ruth E. Uhlmann,Christine Rother,Jay Rasmussen,Juliane Schelle,Carina Bergmann, Emily M. Ullrich Gavilanes,Sarah K. Fritschi,Anika Buehler,Frank Baumann,Angelos Skodras, Rawaa Al-Shaana,Natalie Beschorner,
Brain Structure and Functionno. 8 (2020): 2521-2531
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