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House dust mites are microarthropods that occur in most human homes in humid geographical areas, and these organisms are known to be a major cause of house dust allergy. The mites live in the dust in mattresses, carpets and upholstered furniture where they feed on shed skin scales. Storage mites occur in stored grains and food made from grains, barn dust, and livestock feed and they may occur in homes too. Like house dust mites, storage mites also sensitize and induce allergic reactions in humans. Our research concentrates on characterization of the response of human skin cells to molecules from house dust and storage mites and the allergic response in dust sensitive individuals. Also, various aspects of the mite biology and ecology that allows these organisms to survive in the microenvironment in homes are being investigated.
Scabies is an important mite-caused, widespread, highly contagious skin disease of humans and other mammals. Little is known about the biology of the mite and the host-parasite interactions. We are investigating the host inflammatory and immune response mechanisms in cells of the skin to scabies mites and how the parasite modulates these responses. Our goal is to develop a better understanding of the host-parasite relationship that will lead to development of novel strategies for prevention, control and treatment of this disease.
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Ryenne N Ogburn,Thomas A Randall,Yingrong Xu, Julia H Roberts,Betelihem Mebrahtu,Jaret M Karnuta,S Dean Rider,Grace E Kissling,Robert E London,Anna Pomés,Larry Arlian,Michael C Fitzgerald,
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENEno. SUP5 (2017): 52-52
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