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个人简介
Defining the mechanisms of virus replication and understanding the role of immune cells and host factors in regulating viral infection are essential for developing effective therapeutic strategies. Dr. Wu’s lab studies the mechanisms of HIV and SARS-CoV-2 replication, virus interaction with host factors, and anti-viral innate immunity. The lab focuses on the mechanisms of HIV-1 restriction by the host protein SAMHD1, a unique cellular dNTP triphosphohydrolase that regulates dNTP homeostasis and maintains genomic stability. The lab also investigates the mechanisms by which N6-methyladenosine (m6A) modifications of viral and cellular RNA regulate virus gene expression and the host cell response to infection. These mechanistic studies can lay the foundation to facilitate the development of more effective interventions against viral infections.
研究兴趣
论文共 202 篇作者统计合作学者相似作者
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Alice Baek,Ga-Eun Lee,Sarah Golconda, Asif Rayhan, Anastasios A Manganaris,Shuliang Chen,Nagaraja Tirumuru,Hannah Yu,Shihyoung Kim, Christopher Kimmel,Olivier Zablocki,Matthew B Sullivan,
Advanced Functional Materialsno. 12 (2023): 2212277-2212277
Microbiology spectrumno. 1 (2023)
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Yingke Tang,Ryan T. Behrens,Corine St Gelais,Siqi Wu, Saravanan Vivekanandan,Ehud Razin,Pengfei Fang,Li Wu,Nathan Sherer,Karin Musier-Forsyth
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINEno. 6 (2023)
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The Journal of biological chemistryno. 6 (2023): 104750-104750
Alice Baek,Ga‐Eun Lee,Sarah Golconda, Ashyad Rayhan, Anastasios Manganaris,Shuliang Chen,Nagaraja Tirumuru, Hannah Yu,Shihyoung Kim, Carole A. Kimmel,Olivier Zablocki,Matthew B. Sullivan,
Research Square (Research Square) (2023)
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