Major Areas of Research
Defining the molecular and cellular bases of novel forms of human inborn errors of immunity
Understanding the mechanisms underpinning manifestations of immune dysregulation in patients with RAG deficiency and other forms of combined immune deficiency
Defining the cellular and transcriptional diversity of thymic stromal and hematopoietic cells in health and disease both in humans and in mice
Modeling pathological human T cell development in vitro
Developing novel approaches to correct primary immune deficiency gene defects
Analysis of the inflammatory response and composition of T- and B-Cell Repertoire and Mapping of Virus-Specific T-Cell Receptor Sequences in patients with COVID-19 and MIS-C