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My lab is focussed on the development of new experimental and computational technologies to help us understand the mechanisms underlying cell function. We have a longstanding effort aimed at developing and characterizing fluorescent probes of membrane potential. This effort is continuing, using organic chemical design and synthesis to develop better more sensitive voltage indicators. This work has led to a continual interest in the organization of signaling pathways along the cell membrane and within the cytoplasm. We are interested in the very general question of how the intricate spatial organization of molecules in cells is used to control cell function. This is especially true of neuronal cells and we are actively investigating the cell biology of dendritic spines in brain tissue. This motivated us to develop a very general computational modeling software platform called the "Virtual Cell", in which we have created a framework for using computer simulation to explore cell biological mechanisms. The models are built naturally from experimental images of cellular and subcellular structures combined with biochemical and electrophysiological data. We have used the “Virtual Cell” system to explain the pattern of electrical and signaling activity in neuronal and non-neuronal cells. Most recently, we have developed new software called SpringSaLaD that can model molecular interactions at the sub-cellular scale. This allows us to explaore how the shape of individual molecules control their interactions, leading ultimately to cell-level responses.
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Marina Scardigli,Michal Pasek,Lorenzo Santini,Chiara Palandri, Emilia Conti,Claudia Crocini,Marina Campione,Leslie M. Loew, Antoine A. F. de Vries,Daniel A. Pijnappels,Francesco S. Pavone,Corrado Poggesi,
JOURNAL OF PHYSIOLOGY-LONDONno. 5 (2024): 791-808
Pflugers Archiv : European journal of physiologyno. 11 (2023): 1357-1366
Frontiers in physiology (2023): 1167524
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Daniel Enríquez-Vázquez,Jorge G. Quintanilla, Alba García-Escolano, Marinela Couselo-Seijas,Ana Simón-Chica,Peter Lee,José Manuel Alfonso-Almazán,Patricia Mahía,Andrés Redondo-Rodríguez,Javier Modrego,Adriana Ortega-Hernández,Pedro Marcos-Alberca,
Nature Communicationsno. 1 (2023): 1-17
Ping Yan,Corey D. Acker,Valentina Biasci, Giuliana Judge, Alexa Monroe,Leonardo Sacconi,Leslie M. Loew
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 34 (2023): e2305093120-e2305093120
bioRxiv : the preprint server for biologyno. 6 (2023)
2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (2023): 1-4
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