基本信息
浏览量:335
职业迁徙
个人简介
Complex biological processes often require in vivo analysis. A fundamental understanding of many biological processes in humans has stemmed from experimental studies in animal models, particularly in laboratory mice. For several decades, our lab has studied the molecular and cellular basis for pathological changes caused by spontaneous mutations that disrupt the development or regulation of the murine hematopoietic and immune systems. This knowledge has increased our understanding of human disease. Certain mutations result in severe combined immunodeficiency disease (SCID). We have applied the knowledge gained in our studies of SCID mice to optimize them to serve as hosts for human normal and malignant cells and tissues. There is a growing need for animal models to carry out research studies without putting human individuals at risk. We have developed SCID mouse models that support high levels of engraftment with human cells and tissues to overcome these limitations. We have collaborated nationally and internationally with colleagues to develop improved humanized mouse models and optimize the technologies used for engraftment of normal and malignant human cells and tissues. Our research has leveraged these models for translational studies on human hematopoiesis, immunity, autoimmunity, infectious diseases, diabetes, regenerative medicine and cancer.
研究兴趣
论文共 521 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Mason McCrury,Kennith Swafford, Sydnye L. Shuttleworth,Syed Hassan Mehdi,Baku Acharya,Debasmita Saha, Kevin Naceanceno,Stephanie D. Byrum,Aaron J. Storey,Ying-Zhi Xu, Claire Doshier,Vijay Patel,
biorxiv(2024)
Natalia M. Del Rio,Liupei Huang, Lydia Murphy, Jayalaxmi Suresh Babu, Cross Matthew Daffada, William John Haynes,James G. Keck,Michael. A. Brehm,Leonard D. Shultz,Matthew E. Brown
Jiwon Yang, Jing Jiao, Kyle M. Draheim, Guoxiang Yang, Hongyuan Yang, Li-Chin Yao,Leonard D. Shultz,Dale L. Greiner, Deepa Rajagopal,Sandrine Vessillier,Curtis C. Maier,Sunish Mohanan,
FASEB JOURNALno. 6 (2023): e22995-e22995
Molly A. Harris, Hyuna Yang,Benjamin E. Low, Joydeep Mukherje, Abhijit Guha,Roderick T. Bronson,Leonard D. Shultz,Mark A. Israel,Kyuson Yun
crossref(2023)
Journal of leukocyte biologyno. 5 (2023): 418-433
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn