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We are currently examining the role of tumor suppressor genes in cancer. Tumor suppressor genes encode negative regulators of cell growth and are often mutated in human cancers. The p53 tumor suppressor gene is our current focus. About half of all human cancers have mutations in the p53 gene, indicating that loss of its function is an important contributing factor in cancer development. p53 acts as a transcription factor that regulates many target genes that participate in cell cycle checkpoints that respond to DNA damage or initiate programmed cell death (apoptosis). In either case, the cell will be prevented from propagating damaged DNA templates that may ultimately form oncogenic lesions and increase the likelihood of the cell becoming cancerous. Thus, p53 is critical for preservation of genomic integrity and cancer prevention.
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crossref(2023)
HemaSphereno. S1 (2019): 51-52
Lawrence A. Donehower,Thierry Soussi, Anil Korkut,Yuexin Liu,Andre Schultz,Maria F. Cardenas,Xubin Li,Özgün Babur,Teng-Kuei Hsu,Olivier Lichtarge,John N. Weinstein, Rehan Akbani,
Cell Reportsno. 11 (2019)
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