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个人简介
My research career has focussed on the inter-related themes of membrane protein function and the role of glycosylation in biology.
I studied the erythrocyte anion transporter as a model integral membrane protein, using protein chemical methods to demonstrate that it has a multi-spanning transmembrane topology. As a postdoctoral fellow, I became interested in hepatic receptors that clear glycoproteins from serum, initially as model endocytic receptors that would be tractable to experimental analysis. I established their primary structures and demonstrated that these receptors have a novel 'type II' transmembrane orientation, in which the N-terminus faces the cytoplasm. Cloning and in vitro expression studies were then used to show that transmembrane anchors in these proteins serve as internal, uncleaved signal sequences. Thus, these studies were instrumental in defining some of the major classes of integral membrane proteins.
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论文共 91 篇作者统计合作学者相似作者
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HAL (Le Centre pour la Communication Scientifique Directe) (2022)
Sabine A F Jégouzo, Conor Nelson, Thomas Hardwick, S T Angel Wong,Noel Kuan Kiat Lau, Gaik Kin Emily Neoh,Rocío Castellanos-Rueda,Zhiyao Huang, Benjamin Mignot,Aanya Hirdaramani,Annie Howitt, Kathryn Frewin,
Sabine A F Jégouzo,Hadar Feinberg, Andrew G Morrison,Angela Holder,Alisha May,Zhiyao Huang, Linghua Jiang,Yi Lasanajak,David F Smith,Dirk Werling,Kurt Drickamer,William I Weis,
The Journal of biological chemistryno. 41 (2019): 14845-14859
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