基本信息
浏览量:35
职业迁徙
个人简介
Research Area
The research interest of Mei lab focuses on the molecular mechanism underlying the regulation of vesicle trafficking. Vesicle trafficking is a fundamental cellular process by which membrane-encapsulated vesicles, including synaptic vesicles, transport materials between different cellular compartments and between a cell and its environment. Malfunction of vesicle trafficking will cause a broad spectrum of severe diseases, such as cancer, diabetes, immune deficiency and neuropathy. Vesicle trafficking occurs in four steps including vesicle biogenesis, transport, docking and fusion with the target membrane, each of which is mediated by a specific concert of protein families. Membrane fusion is mediated by the SNAREs and docking is manly mediated by the MTCs (Multi-subunit tethering complexes). MTCs are conserved in eukaryotes and different MTCs are involved in different stages of the secretory and endocytic pathway. MTCs not only mediate vesicle docking via tethering the trafficking vesicles to the target membrane, but also interact with the SNAREs to promote membrane fusion between them (Figure 1). However, the molecular mechanisms underlying these cellular processes are largely unknown.
The research interest of Mei lab focuses on the molecular mechanism underlying the regulation of vesicle trafficking. Vesicle trafficking is a fundamental cellular process by which membrane-encapsulated vesicles, including synaptic vesicles, transport materials between different cellular compartments and between a cell and its environment. Malfunction of vesicle trafficking will cause a broad spectrum of severe diseases, such as cancer, diabetes, immune deficiency and neuropathy. Vesicle trafficking occurs in four steps including vesicle biogenesis, transport, docking and fusion with the target membrane, each of which is mediated by a specific concert of protein families. Membrane fusion is mediated by the SNAREs and docking is manly mediated by the MTCs (Multi-subunit tethering complexes). MTCs are conserved in eukaryotes and different MTCs are involved in different stages of the secretory and endocytic pathway. MTCs not only mediate vesicle docking via tethering the trafficking vesicles to the target membrane, but also interact with the SNAREs to promote membrane fusion between them (Figure 1). However, the molecular mechanisms underlying these cellular processes are largely unknown.
研究兴趣
论文共 30 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Protein expression and purification (2024): 106430-106430
Qingyun Zhang,Yi Yang,Jun Lan,Ziyi Wang,Yan Gao,Xiao Li, Weidong Mao,Jing Xie, Li-Zhi Mi,Xiangyang Zhang,Xinquan Wang,Xin Mu,
FRONTIERS IN IMMUNOLOGY (2023): 1259386-1259386
International Symposium on Artificial Intelligence in Medical Sciencespp.1218-1222, (2023)
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2023): 5358-5371
Qiushuang Ji, Ke Zhang, Na Cao, Xiaoyu You,Shuaihua Cao, Mengya Wang, Jiatian Guo,Hongwei Wang,Kunrong Mei
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn