基本信息
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Career Trajectory
Bio
Working with Xiao Zhen Zhou, he discovered Pin1-catalyzed prolyl isomerization as a novel post-phosphorylation signaling mechanism in health and disease, having the opposite effect on cancer and Alzheimer’s disease, two major aging diseases that were rarely studied together before. Their current focuses are to elucidate cis-trans conformational changes in disease development, and to develop Pin1-targeted therapies, including Pin1 inhibitors to block multiple cancer-driving pathways and eliminate cancer stem cells, and cis P-tau antibody to neutralize a major early driver of neurodegeneration in Alzheimer’s and brain injury. His honors include Leukemia and Lymphoma Society of America Scholar (1998), Pew Scholar in Biomedical Sciences (1999), Young Investigator Award from Chinese Biological Investigator Society (1999), Elected Member of American Society for Clinical Investigation (2007), Elected Fellow of American Association for Advancement of Science (2012), and Elected Member of Association of American Physicians (2013).
Research Interests
Papers共 277 篇Author StatisticsCo-AuthorSimilar Experts
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Chenxi Qiu, Zhixiong Li,David A. Leigh,Bingbing Duan, Joseph E. Stucky,Nami Kim, George Xie,Kun Ping Lu,Xiao Zhen Zhou
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2024): 1343962-1343962
NATURE COMMUNICATIONSno. 1 (2024)
Nature Communicationsno. 1 (2024): 1-21
Kun Ping Lu, Xiao Zhen Zhou
Science signalingno. 841 (2024): eadi8743-eadi8743
Nature communicationsno. 1 (2024): 3220-3220
Xiaoyan Zeng, Stanley K. K. Cheung,Mengqi Shi,Penelope M. Y. Or,Zhining Li,Julia Y. H. Liu,Wayne L. H. Ho,Tian Liu,Kun Lu,John A. Rudd,Yubing Wang,Andrew M. Chan
Journal of Neuroinflammationno. 1 (2023): 1-15
Research square (2023)
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