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个人简介
My research is focused in areas of Drug Development and Neuroscience. My research integrates fields of molecular biology, cell science, and drug discovery. It integrates the areas of cell biology, medicine and pharmaceuticals. I established the Drug Development group at Trinity, which investigates mechanisms underlying brain diseases, particularly demyelinating diseases such as Multiple Sclerosis, and also with a focus on rare paediatric illnesses including Krabbes disease (KD). KD causes fatality in infants and has no cure. My group has identified new compounds, repositioned marketed drugs, developed novel nanoparticle technology and created nasal delivery methods that demonstrate efficacy models of KD. These findings are published in top-tier neuroscience and neurotherapeutic journals and are of international recognition. This research is translational, where the developed technologies are on a potential path of clinical development, subject of patent application, commercialisation and the basis of EU grant applications, supported by Enterprise Ireland. My research has transformed our understanding of how marketed drugs used in Multiple Sclerosis work, and how they directly regulate brain cells. This work is pioneering, highly cited and uncovered novel cell mechanisms leading to development of new therapeutic strategies. This work demonstrates an ongoing transformational nature of my activities. My research is competitively recognised and well supported by national and international funding agencies as well as multinational pharmaceutical industry and biotech. I have been awarded over 5.7 million in funding, published almost 100 papers and have an H-index of over 40. I am a board member and reviewer of several international journals, advisor and consultant to large pharmaceutical and biotech companies and I have been President of Frontier of Neurology Ireland for 7 years, bringing to Ireland and Trinity links from across Europe and US, and bringing support from multiple large pharma and research funding agencies. My work has also been highlighted in national press in the area of neurology and drug development. I have significant expertise in drug development and a global network within multiple pharma and biotech industry. I have provided leadership to large research and drug discovery projects and successfully delivered follow-on compounds of marketed drugs, for Multiple Sclerosis. I have published extensively in my area of research of brain cell biology, specifically glial cells. The journal Glia is the highest journal in this field in which my research is being published on a yearly basis. A pubmed search in my focussed area indicates 10% of articles being from my group, many are highly cited. The approaches used by my group, integrating human brain cells and brain slice studies are also unique. The drug testing platform established in my group attracts multiple industry collaborations. I am regularly invited as a Consultant to guide and review drug development projects. I have provided Consultant assistance to drug development of nearly 100 various pharma and biotech companies. With these activities, I have a world leader recognition in my area of drug development. My mission is to teach within the emerging field of drug development as well as develop new medicines.
研究兴趣
论文共 160 篇作者统计合作学者相似作者
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Sibylle Béchet,Kumlesh K Dev
Biomedicinesno. 3 (2024)
Molecular Neurobiologypp.1-14, (2024)
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsno. 5 (2023): 1347-1368
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacologyno. 4 (2023): 592-609
Biopharma Dealmakers (2023)
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Jennifer Moran,Eimear Mylod,Laura E Kane, Caroline Marion, Emily Keenan,Marianna Mekhaeil,Joanne Lysaght,Kumlesh K Dev,Jacintha O'Sullivan,Melissa J Conroy
Biomedicinesno. 5 (2023): 1313-1313
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