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Professor Kum Kum Khanna and her group have made numerous contributions to understanding the normal functions of the ATM protein, a central controller of cellular responses to DNA damage and how it suppresses cancer. The group also identified and functionally characterized the Cep55 protein as a new regulator of cytokinesis, the final stage of cell division that divides the cytoplasm equally amongst two daughter cells. More recently, they identified two novel Single-Stranded DNA (ssDNA) Binding proteins, named as SSB1 and SSB2, which play a critical role in the maintenance of genomic stability. Through the NHMRC funded Program grant, Professor Khanna’s group have worked actively to bridge the gap between basic and applied research. They have developed a novel combination therapy against breast cancer, involving targeted radioimmunotherapy with a DNA repair inhibitor and chemotherapy. They have also performed functional screens and have discovered therapeutic targets that regulate primary tumour growth and metastasis of triple-negative breast cancer.
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论文共 319 篇作者统计合作学者相似作者
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PROTEOMICSpp.e2300089-e2300089, (2024)
Trends in pharmacological sciencesno. 3 (2024): 210-224
Armando van der Horst,Kum Kum Khanna
crossref(2023)
Behnam Rashidieh,Amanda Louise Bain,Simon Manuel Tria, Sowmya Sharma, Cameron Allan Stewart,Jacinta Ley Simmons,Pirjo M. Apaja,Pascal H. G. Duijf,John Finnie,Kum Kum Khanna
Cell & bioscienceno. 1 (2023): 132-19
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Christelle Morris, Nozomi Tomimatsu,Derek J. Richard,David Cluet,Sandeep Burma,Kum Kum Khanna,Pierre Jalinot
crossref(2023)
Armando van der Horst,Kum Kum Khanna
crossref(2023)
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