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We are interested in Schwann cells, the glial cells of peripheral nerves. These cells provide signals, which during development are required for neuronal survival, and which are essential for the integrity of peripheral nerves in the adult. They also make myelin-sheaths around axons that are needed for the normal conduction of nerve impulses. In damaged nerves, Schwann cells guide re-growing axons and make nerve repair possible.
Schwann cells show a striking ability to de-differentiate. This happens for instance when nerves are injured and it is phenotypic plasticity that generates an environment that supports axon growth and nerve regeneration. But Schwann cell de-differentiation and de-myelination is also a major problem in the common inherited and acquired peripheral neuropathies.
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Peripheral Nerve Tissue Engineering and Regenerationpp.385-401, (2022)
Laura J Wagstaff,Jose A Gomez-Sanchez,Shaline V Fazal,Georg W Otto,Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong,Ki H Ma,Mark Turmaine,John Svaren,Tessa Gordon,Peter Arthur-Farraj,
crossref(2020)
Regenerative Medicine and Plastic Surgerypp.425-435, (2019)
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