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Dr. Kiick’s group investigates the synthesis, characterization, and application of biologically inspired and biologically produced materials that are largely based on the structural proteins collagen, elastin, and resilin. The unique phase behavior of these protein- and peptide-based materials is being exploited to produce novel nano- and micro-structured materials with potential therapeutics uses in cardiovascular disease, wound healing, tendon repair, and treatment of various arthroses. These projects exploit the control of polymer architecture afforded by the use of proteins and peptides, which enables nuanced control of assembly; students in the group employ a varied combination of materials synthesis and characterization methods. Protein engineering strategies are used to produce designed protein materials; biochemical methods are employed for protein purification; chemical methods are used to modify the proteins with appropriate ligands. Immunochemical assays, scattering methods, optical microscopy, electron microscopy, and cell culture are also utilized as appropriate to characterize these polymeric systems. The production of these unique macromolecular systems will expedite the development of new biomaterials and therapeutic strategies.
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CHEMISTRY-A EUROPEAN JOURNALpp.e202400582-e202400582, (2024)
Shiv Rekhi, Cristobal Garcia Garcia, Mayur Barai,Azamat Rizuan,Benjamin S. Schuster,Kristi L. Kiick,Jeetain Mittal
NATURE CHEMISTRYpp.1-12, (2024)
Luisa L. Palmese,Paige J. Levalley,Lina Pradhan, Amanda L. Parsons,John S. Oakey,Mathew Abraham, Suzanne M. D'Addio,April M. Kloxin,Yingkai Liang,Kristi L. Kiick
Biomacromoleculesno. 8 (2023): 3729-3741
ACS applied materials & interfacesno. 13 (2023): 16434-16447
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