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Molecular life sciences: analysis and pathobiochemistry of lysosomal storage diseases,
including therapeutic approaches, structure and function of lysosomal proteins (enzymes and
activator proteins), topology of endocytosis and glycolipid metabolism, regulation of
glycolipid biosynthesis, analysis of the sphingolipid metabolism involved in the biogenesis of
the water permeability barrier of the skin, enzymology at membrane surfaces, and chemical
synthesis of glycolipid derivatives. Role of lipid binding and transfer proteins in the catabolism
of sphingolipids and cellular membrane digestion.
Methodology used by the research team includes chemical synthesis, lipid and protein
chemistry, methods of molecular biology (cloning and expression of cDNAs), biotechnology
(preparative expression of recombinant enzymes and membrane active glycoproteins, their
purification and characterization using physico-chemical techniques).
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Free neuropathology (2023)
Advances in Neurobiology Glycobiology of the Nervous Systempp.333-390, (2022)
International journal of molecular sciencesno. 16 (2021): 9001
Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Diseasepp.547-557, (2020)
Nesli-Ece Sen,Aleksandar Arsovic,David Meierhofer,Susanne Brodesser, Carola Oberschmidt,Júlia Canet-Pons, Zeynep-Ece Kaya,Melanie V. Halbach,Suzana Gispert,Konrad Sandhoff, Georg Auburger
crossref(2019)
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