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We have developed the highly efficient transposon system in vertebrates by using the Tol2 transposable element from Japanese medaka fish. Further, in a model vertebrate zebrafish, we have developed powerful genetic methods, including the transposon-mediated transgenesis, gene trap, enhancer trap, and Gal4-UAS methods. By using these methods, we created a large number of transgenic fish lines that express the yeast Gal4 transcription activator in specific cells, tissues and organs. We are collaborating researchers all over the world based on the transgenic fish resources. Furthermore, we are studying the structure and function of specific neuronal circuits that regulate complex behaviors such as learning and memory by genetic approaches and calcium imaging.
(A) Adult zebrafish. (B, C) Neuronal circuits essential for fear conditioning in zebrafish (Lal et al. 2018). (D) Prey hunting in zebrafish (Muto et al. 2017). (E) A developmental mechanism of abducens neurons in zebrafish (Asakawa and Kawakami 2018).
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论文共 314 篇作者统计合作学者相似作者
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Yuki Otsuka, Keiko Imamura,Akio Oishi,Kazuhide Asakawa,Takayuki Kondo, Risako Nakai,Mika Suga,Ikuyo Inoue, Yukako Sagara,Kayoko Tsukita, Kaori Teranaka, Yu Nishimura,
DEVELOPMENTAL DYNAMICS (2024)
Shuzhang Liang,Yating Zhou, Yue Chang, Jiayi Li,Min Zhang, Peng Gao, Qi Li,Hong Yu,Koichi Kawakami,Jinmin Ma,Ruilin Zhang
Developmental dynamics : an official publication of the American Association of Anatomists (2024)
Nature communicationsno. 1 (2023): 6020-17
Maiko Inotsume,Tomoki Chiba, Taijiro Matsushima,Ryota Kurimoto, Mitsuyo Nakajima,Tomomi Kato,Kana Shishido,Lin Liu,Koichi Kawakami,Hiroshi Asahara
FEBS Lettersno. 7 (2023): 975-984
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