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The primary objective of my research is to develop sensitive and specific methods for the determination of well-known or suspected "endocrine disrupting chemicals" in human blood and urine samples of individuals exposed at the workplace or via the environment. Particular focus is on phthalates (e.g. DEHP, DBP, DINP, etc.) and their substitutes (DINCH, terephthalates, adipates), non-persistent pesticides and fungizides (e.g. organophosphorus compounds, pyrethoids, vinclozoline, etc.), UV-filters and solvents by using 2-dimensional high performance liquid chromatography and tandem mass spectrometry (LC-MS/MS) as well as metals (e.g. cadmium and manganese) employing atomic absorption spectroscopy or ICP-MS. Particular focus is also on the metabolism and elimination kinetics of these compounds in-vivo. For this purpose, stable isotope labelled compounds are ingested by volunteers or in animal experiments and blood and urine are subsequently analysed for suspected metabolites. Overall aim is to identify appropriate biomarkers of exposure which in turn can be used in larger-scale molecular epidemiological studies to provide additional data for risk assessment in humans, in particular possible susceptible subgroups such as children and persons in reproductive age. Finally, the data can be used to identify causal relationships between exposure and endocrine effects in humans.
The primary objective of my research is to develop sensitive and specific methods for the determination of well-known or suspected "endocrine disrupting chemicals" in human blood and urine samples of individuals exposed at the workplace or via the environment. Particular focus is on phthalates (e.g. DEHP, DBP, DINP, etc.) and their substitutes (DINCH, terephthalates, adipates), non-persistent pesticides and fungizides (e.g. organophosphorus compounds, pyrethoids, vinclozoline, etc.), UV-filters and solvents by using 2-dimensional high performance liquid chromatography and tandem mass spectrometry (LC-MS/MS) as well as metals (e.g. cadmium and manganese) employing atomic absorption spectroscopy or ICP-MS. Particular focus is also on the metabolism and elimination kinetics of these compounds in-vivo. For this purpose, stable isotope labelled compounds are ingested by volunteers or in animal experiments and blood and urine are subsequently analysed for suspected metabolites. Overall aim is to identify appropriate biomarkers of exposure which in turn can be used in larger-scale molecular epidemiological studies to provide additional data for risk assessment in humans, in particular possible susceptible subgroups such as children and persons in reproductive age. Finally, the data can be used to identify causal relationships between exposure and endocrine effects in humans.
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FRONTIERS IN PUBLIC HEALTH (2024): 1321138-1321138
Archives of Toxicologyno. 5 (2024): 1-16
TALANTAno. Pt 1 (2024): 124974-124974
ENVIRONMENTAL SCIENCE & TECHNOLOGYno. 32 (2023): 11926-11936
International journal of hygiene and environmental health (2023): 114101-114101
ENVIRONMENTAL HEALTH PERSPECTIVESno. 7 (2023): 71304-71304
J.S. Burns,J.R. Bather,O. Sergeyev, M.M. Lee,S.A. Korrick,S. Sokolov,S. Kovalev,H.M. Koch, A.T. Lebedev, L. Mínguez-Alarcón,R. Hauser,P.L. Williams
Environmental Research (2023): 116330-116330
ENVIRONMENTAL SCIENCE & TECHNOLOGYno. 48 (2023): 19285-19294
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