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In the research supported by the G-COE program, we focus on the neuropharmacological study to develop novel drugs in neuropsychiatric disorders such as schizophrenia. Interactions of environmental and genetic factors may play a role in the pathoetiology of schizophrenia. Some potential environmental insults, such as viral infection and stress during the developmental stage could affect brain development. We have previously demonstrated that neonatal injection of polyriboinosinic-polyribocytidylic acid (polyI:C) in ICR mice, which elicits a strong innate immune response, induces schizophrenia-like behavioral alterations with an impairment of glutamate release in the hippocampus in adulthood. We suggested that the induction of IFITM3 in astrocytes during the early neonatal period might play a crucial role in neurodevelopmental disturbance induced by polyI:C treatment. Furthermore, we have reported a novel animal model for schizophrenia by inducing abnormal immune response with polyI:C treatment during the perinatal period in transgenic mice with human dominant-negative form of disrupted-in-schizophrenia 1. Besides, we identified neuronal PAS domain 4 (Npas4) as a stress-responsible transcription factor that regulates neuronal function. In 2011, we investigated the role of IFITM3 in astroglial cells. Furthermore, we investigated the role of Npas4 in neurodevelopment and neuropsychological function.
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论文共 779 篇作者统计合作学者相似作者
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STROKE-VASCULAR AND INTERVENTIONAL NEUROLOGYno. 5 (2023)
Yasuhiro Funahashi,Rijwan Uddin Ahammad,Xinjian Zhang,Emran Hossen,Masahiro Kawatani,Shinichi Nakamuta,Akira Yoshimi, Minhua Wu, Huanhuan Wang,Mengya Wu, Xu Li,Md. Omar Faruk,
biorxiv(2023)
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Rinako Tanaka,Jingzhu Liao,Daisuke Mori,Taku Nagai, Tetsuo Matsuzaki,Toshitaka Nabeshima,Kozo Kaibuchi,Norio Ozaki, Hiroyuki Mizoguchi,Kiyofumi Yamada
BRITISH JOURNAL OF PHARMACOLOGY (2023): 1004-1004
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Hiroyuki Mizoguchi,Kentaro Katahira,Ayumu Inutsuka,Ryosuke Kaneko, Mizuki Kusaba, Tian Wang,Yutao Dong, Haruna Iida,Kazuya Fukumoto,Yuchio Yanagawa,Akihiro Yamanaka,Kiyofumi Yamada
crossref(2023)
Rinako Tanaka,Kiyofumi Yamada
International Journal of Molecular Sciencesno. 21 (2023): 15623-15623
medRxiv (Cold Spring Harbor Laboratory) (2023)
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