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职业迁徙
个人简介
Research Topics
Noroviruses in the Caliciviridae are a major cause of acute gastroenteritis in all age groups. The illness occurs often in settings where people are in close contact, such as families, nursing homes, hospitals, schools, camps, cruise ships, military barracks, and social gatherings. In most individuals, norovirus gastroenteritis (known commonly as “stomach flu”) resolves in two to three days. However, in patients with underlying conditions such as immunosuppression or in the very old and young, the illness can become life-threatening. There are presently no approved vaccines or specific antiviral drugs for the noroviruses, and the overall goal of this research program is to advance their development.
One of the major specific areas of research in our laboratory is to develop experimental systems in which to study norovirus replication and immunity. The inability to grow the human noroviruses associated with acute gastroenteritis has been a major research obstacle. We have conducted comparative studies among diverse members of the Caliciviridae in an effort to learn common themes in calicivirus replication that will inform our understanding of the human noroviruses. Recent breakthroughs include the first visualization of calicivirus replication in real time by the introduction of a fluorescent protein marker in the feline calicivirus genome, a proof of concept study for human norovirus vaccines in an animal model, and the mapping of functional epitopes in a predominant norovirus genotype.
In recent years, her research program has addressed the role of noroviruses in human disease, with an emphasis on the development of prevention and control strategies.
Memberships
American Society for Virology
American Society for Microbiology
Caliciviridae Study Group, International Committee on Taxonomy of Viruses
研究兴趣
论文共 210 篇作者统计合作学者相似作者
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Inga Rimkute,Natthawan Chaimongkol,Kamron D. Woods,Bianca M. Nagata,Samuel Darko, Sucheta Gudbole,Amy R. Henry,Stanislav V. Sosnovtsev,Adam S. Olia,Raffaello Verardi,Karin Bok,John-Paul Todd,
Journal of medical virologyno. 6 (2023)
European journal of hospital pharmacy : science and practice (2023)
引用3浏览0WOS引用
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Nature Communicationsno. 1 (2023): 1-11
Natthawan Chaimongkol,Nathania Dabilla,Kentaro Tohma, Yuki Matsushima,Allison Behrle Yardley,Eric A. Levenson,Jordan A. Johnson, Courtney Ahorrio,Andrew J. Oler, Daniel Y. Kim,Menira Souza,Stanislav V. Sosnovtsev,
mBiono. 6 (2023)
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European Journal of Hospital Pharmacypp.ejhpharm-003750, (2023)
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biorxiv(2022)
Monatsschrift Kinderheilkundepp.1-2, (2022)
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