His current research interests include query processing and optimization in multiprocessor and distributed systems, database performance, data analytics, and database security. Kian-Lee has published over 300 research articles in international journals and conference proceedings, and co-authored several books/monographs.

Kian-Lee was a recipient of the NUS Outstanding University Researchers Award in 1998, and the NUS Graduate School (NGS) Excellent Mentor Award in 2011. He was a co-recipient of Singapore's President Science Award in 2011. He is also a 2013 IEEE Technical Achievement Award recipient.