基本信息
浏览量:90
职业迁徙
个人简介
Khushi L. Matta
Khushi L.
Matta
Ph.D.
Professor
Roswell Park Cancer InstituteMy laboratory utilizes carbohydrate chemistry to develop synthetic resources for further application in our investigations of glycoprotein biosynthesis. One area of study is the investigation of human galactosyl-, fucosyl-, and sialyltransferases implicated in the biosynthesis of cancer related glycoconjugates. Another program seeks to identify and characterize sulfotransferases present in different tumor cell lines and human tissue, in order to elucidate the biosynthetic pathway of sulfoglycoconjugates.
Information obtained for these programs leads us to develop studies into cell adhesion processes. Cell adhesion plays an important role in chronic inflammatory diseases. In addition, the cell adhesion process may be exploited by cancer cells to metastasize after entering the blood stream. Major effort is being centered on the prevention of initial adhesion events between circulating leukocytes and endothelium involving two families of cell surface receptors: the selectins and integrins. The family of selectins contains three members: E,P and L-selectin. All of our efforts are directed at understanding the glycobiology of cancer and related diseases. Phenotypic characterization of the unique cell surface markers of these stem-like cells may be better than use of cancer cell cultures under conventional methods. We hypothesize that the "glycan signature" of Prostate cancer cells stem cells (PCSCs) differentiates them from non-cancer prostate stem cells (Non-PCSCs), and the "glycan signature" evolves during the pathogenesis of prostate cancer and contributes causally to the disease phenotype.
研究兴趣
论文共 442 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Shuen-Shiuan Wang, Shuai Shao, Arun Singh, Ryoma Hombu,Jonathan F. Lovell,Khushi L. Matta,Sriram Neelamegham
Modern Methods in Carbohydrate Synthesispp.437-466, (2020)
Biochemical and biophysical research communicationsno. 3 (2015): 606-12
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn