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个人简介
I am inspired by the many ways in which scientific discovery can positively transform our lives. My own curiosity has drawn me to the interface of the genetics, stem cell biology and neuroscience fields, ultimately leading to a career in academic science, biotechnology entrepreneurship and the pharmaceutical industry. As a Professor at Harvard University and a Principal Investigator at the Harvard Stem Cell Institute, my research group helped establish that pluripotent stem cells are a valuable source of many differentiated cell types, which can in turn be used to study how human genetic variation shapes cellular phenotypes contributing to disease. Because most cell-types from the human brain cannot be viably retrieved, even at autopsy, we naturally focused our early efforts on studying how genetic factors predispose us to nervous system disorders. Our studies of ALS have been particularly fruitful and demonstrated that alterations in RNA metabolism found in stem cell-derived motor neurons are predictive of those unfolding in patients. These fundamental findings served as the bases for further academic and entrepreneurial collaborations that have generated several therapeutic candidates for ALS, two of which are in active clinical studies. To further my goals of growing the scientific careers of colleagues and using new technologies to bring therapeutic solutions to unmet medical needs of patients with rare genetic disease, I joined BioMarin to lead Research and Early Development and now serve as Chief Scientific Officier
研究兴趣
论文共 218 篇作者统计合作学者相似作者
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Ellen J. Guss, Laila Sathe, Alexander Dai, Tim Derebenskiy, Ana Rodriguez Vega,Kevin Eggan,Michael F. Wells
STAR Protocolsno. 1 (2024): 102878-102878
NATURE COMMUNICATIONSno. 1 (2024): 347-347
Francesco Limone,Alexander Couto,Jin-Yuan Wang,Yingying Zhang,Blake McCourt, Cerianne Huang, Adina Minkin, Marghi Jani, Sarah McNeer,James Keaney, Gaëlle Gillet, Rodrigo Lopez Gonzalez,
Science translational medicineno. 732 (2024): eadg7895-eadg7895
Michael F. Wells,Ellen J. Guss, Haoming Zhou,Bruce Sun,Héctor Martínez,Veronika Akopian,Scott Noggle,Daniel Paull,Jennifer C. Moore, Michael Sheldon, Julia E. Sommer, Marta Benedetti,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Michael-John Dolan,Martine Therrien, Saša Jereb,Tushar Kamath,Vahid Gazestani, Trevor Atkeson,Samuel E. Marsh,Aleksandrina Goeva, Neal M. Lojek,Sarah Murphy,Cassandra M. White,Julia Joung,
Nature Immunologyno. 8 (2023): 1-9
引用2浏览0WOSNATURE引用
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Greta Pintacuda,Yu-Han H. Hsu,Kalliopi Tsafou,Ka Wan Li,Jacqueline M. Martin, Jackson Riseman, Julia C. Biagini, Joshua K. T. Ching,Daya Mena,Miguel A. Gonzalez-Lozano,Shawn B. Egri,Jake Jaffe,
CELL GENOMICSno. 3 (2023): 100250-100250
Francesco Limone,Irune Guerra San Juan,Jana M Mitchell, Janell L M Smith, Kavya Raghunathan,Daniel Meyer,Sulagna Dia Ghosh,Alexander Couto,Joseph R Klim,Brian J Joseph,John Gold,Curtis J Mello,
biorxiv(2023)
Olli Pietiläinen,Aditi Trehan,Daniel Meyer,Jana Mitchell,Matthew Tegtmeyer,Vera Valakh, Hilena Gebre, Theresa Chen,Emilia Vartiainen,Samouil L Farhi,Kevin Eggan,Steven A McCarroll,
Yu-Han H. Hsu,Greta Pintacuda,Ruize Liu,Eugeniu Nacu,April Kim,Kalliopi Tsafou, Natalie Petrossian,William Crotty,Jung Min Suh, Jackson Riseman,Jacqueline M. Martin, Julia C. Biagini,
Yenal B. Lakes,Stefanie L. Moye,Juan Mo,Matthew Tegtmeyer,Ralda Nehme,Maura Charlton, Gabrielle Salinas,Renee M. Mckay,Kevin Eggan,Lu Q. Le
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