Kevan M. Shokat
教授
Department of Chemistry
College of Chemistry, University of California, Berkeley;Howard Hughes Medical Institute;Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco;Department of Cellular and Molecular Pharmacology, University of California, San Francisco
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基本信息
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个人简介
Research in my laboratory is focused on the discovery of new chemical based tools to decipher cellular signaling networks with an emphasis on protein kinases and more recently, GTPases. The analysis of signal transduction pathways has proven challenging using the traditional tools of biochemistry, genetics, and chemistry. Biochemical approaches are often limited in utility because signaling networks span from the cell surface to the control of transcription and translation, confounding reconstitution efforts from purified proteins. Genetic approaches allow specific perturbation of single components in an intact cell or organism, yet are often confounded by the emergent properties of signaling cascades. Chemical and pharmacological approaches enable rapid, reversible, and graded (dose-dependent) inactivation of single components in intact cells or organisms. Unfortunately, highly selective chemical probes (agonists, antagonists, traceable substrates, etc.) of protein kinases are difficult to develop because the 500 protein kinases share highly homologous ATP binding pockets. My laboratory has solved this fundamental problem for the largest family of enzymes in the human genome, protein kinases, by development of a strategy based on a combination of protein engineering and organic synthesis. We have termed this approach chemical genetics.
研究兴趣
论文共 621 篇作者统计合作学者相似作者
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Nature Chemical Biologypp.1-9, (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv : the preprint server for biology (2023)
Jean L. Nakamura,Connie Phong,Emile Pinarbasi,Scott C. Kogan,Scott Vandenberg, Andrew E. Horvai,Bruce A. Faddegon, Dorothea Fiedler,Kevan Shokat,Benjamin T. Houseman, Richard Chao,Russell O. Pieper,
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Cancer Researchno. 11_Supplement (2023): B066-B066
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Miran Jang,Yeonghwan Kim,Hyeran Won,Sangbin Lim, Jyothi K.R, Amarjargal Dashdorj,Yoo Hong Min,Si-Young Kim,Kevan M. Shokat, Joohun Ha,Sung Soo Kim
crossref(2023)
Jean L. Nakamura,Connie Phong,Emile Pinarbasi,Scott C. Kogan,Scott Vandenberg, Andrew E. Horvai,Bruce A. Faddegon, Dorothea Fiedler,Kevan Shokat,Benjamin T. Houseman, Richard Chao,Russell O. Pieper,
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MOLECULAR CANCER RESEARCHno. 5 (2023)
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