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My work examines the genetic regulation of sleep and more importantly, how genetic heterogeneity influences the ability to recover from sleep loss. My research program currently has two foci: 1) to determine if disruptions of biological timing result in sleep-wake disorders and if so, which specific genes are involved and, 2) to determine if sex differences in the risk and severity of sleep abnormalities are chromosomally driven. My lab has recently undertaken a forward genetics approach to identify novel sleep genes. We have characterized a variety of sleep phenotypes in inbred mouse strains in sleep-replete and sleep-deprived conditions. We are expanding this dataset to provide sufficient statistical power for quantitative trait loci (QTL) analysis and subsequent follow-up studies. This endeavor combines a well-established paradigm of comparative phenotyping of a genetically tractable animal model with powerful genetic mapping tools to identify novel sleep-regulatory genes. Consequently, these experiments will not only identify new sleep genes, they will also help verify and clarify previously mapped genes whose roles are not yet clearly defined.
My work examines the genetic regulation of sleep and more importantly, how genetic heterogeneity influences the ability to recover from sleep loss. My research program currently has two foci: 1) to determine if disruptions of biological timing result in sleep-wake disorders and if so, which specific genes are involved and, 2) to determine if sex differences in the risk and severity of sleep abnormalities are chromosomally driven. My lab has recently undertaken a forward genetics approach to identify novel sleep genes. We have characterized a variety of sleep phenotypes in inbred mouse strains in sleep-replete and sleep-deprived conditions. We are expanding this dataset to provide sufficient statistical power for quantitative trait loci (QTL) analysis and subsequent follow-up studies. This endeavor combines a well-established paradigm of comparative phenotyping of a genetically tractable animal model with powerful genetic mapping tools to identify novel sleep-regulatory genes. Consequently, these experiments will not only identify new sleep genes, they will also help verify and clarify previously mapped genes whose roles are not yet clearly defined.
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论文共 44 篇作者统计合作学者相似作者
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H. Craig Heller,Erik Herzog,Allison Brager, Gina Poe,Ravi Allada,Frank Scheer,Mary Carskadon,Horacio O. de la Iglesia, Rockelle Jang,Ashley Montero,Kenneth Wright, Philippe Mouraine,
JOURNAL OF BIOLOGICAL RHYTHMSno. 1 (2024): 5-19
JOURNAL OF NEUROSCIENCE RESEARCHno. 1 (2024): e25290-e25290
bioRxiv : the preprint server for biology (2024)
Mary Dover, Taylor Moseley, Adrienne Biskaduros, Mousumi Paulchakrabarti,Sung Hee Hwang,Bruce Hammock,Biswa Choudhury,Karolina Elżbieta Kaczor-Urbanowicz,Andrzej Urbanowicz,Marco Morselli,Johnny Dang,Matteo Pellegrini,
bioRxiv : the preprint server for biology (2023)
SLEEPno. 9 (2023)
Scott M Vincent, Melika Madani, Dante Dikeman, Kyle Golden, Naomi Crocker, Cameron Jackson, Sam P Wimmer, Mary Dover, Alexis Tucker,Cristina A Ghiani, Christopher S Colwell,Tyler W LeBaron,
Sleep advances : a journal of the Sleep Research Societyno. 1 (2023): zpad057-zpad057
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