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Small molecule and antibody modulators of the immune system have proven efficacious in the treatment of cancer, infectious diseases and autoimmune disorders. These successes underline the need for other immunomodulatory agents, in particular cell-penetrating small molecules, that can target proteins inaccessible to monoclonal antibodies. Combining chemical proteomics and activity-based protein profiling (ABPP), we synthesize new probes and develop new methods to study and manipulate the human immune system.
Small molecule and antibody modulators of the immune system have proven efficacious in the treatment of cancer, infectious diseases and autoimmune disorders. These successes underline the need for other immunomodulatory agents, in particular cell-penetrating small molecules, that can target proteins inaccessible to monoclonal antibodies. Combining chemical proteomics and activity-based protein profiling (ABPP), we synthesize new probes and develop new methods to study and manipulate the human immune system.
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论文共 45 篇作者统计合作学者相似作者
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STAR PROTOCOLSno. 1 (2024): 102865-102865
crossref(2023)
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 39 (2023): 21303-21318
R M Naseer Khan,Yong-Mo Ahn,Gwendolyn A Marriner,Laura E Via,Francois D'Hooge,Seung Seo Lee, Nan Yang, Falguni Basuli,Alexander G White,Jaime A Tomko,L James Frye,Charles A Scanga,
bioRxiv : the preprint server for biology (2023)
JACS AUno. 12 (2023): 3506-3523
Ashley R Julio,Flowreen Shikwana, Cindy Truong,Nikolas R Burton, Emil Dominguez, Alexandra C Turmon,Jian Cao,Keriann Backus
bioRxiv : the preprint server for biology (2023)
José O Castellón,Samuel Ofori,Ernest Armenta,Nikolas Burton,Lisa M Boatner, Evan E Takayoshi, Marina Faragalla, Annie Zhou,Ky Tran, Jeremy Shek,Tianyang Yan,Heta S Desai,
bioRxiv : the preprint server for biology (2023)
Cell chemical biologyno. 6 (2023): 683-698.e3
bioRxiv : the preprint server for biology (2023)
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