基本信息
浏览量:2
职业迁徙
个人简介
Areas of Interest
The evolution of the cerebral cortex is thought to underlie the human brain’s most remarkable cognitive, perceptive, and motor capabilities. Miswiring of cortical circuitry during development can lead to disorders, including autism and schizophrenia, that affect the most distinctly human cognitive functions.
The Kwan laboratory focuses on examining the fundamental and pathogenic mechanisms that can have in vivo consequences for neural circuit development and function. They aim to understand the molecular and cellular mechanisms that underlie normal neural circuit assembly in the cerebral cortex, and the role circuit dysregulation plays in human neurodevelopmental disorders, in particular autism spectrum disorder, fragile X syndrome, and schizophrenia.
The lab’s overarching research goals are: 1) to understand the mechanisms by which neural progenitor cells give rise to diverse repertoires of cortical neuronal subtypes; and 2) to understand the mechanisms that ultimately wire cortical neurons into functional neural circuits. An integrative approach is used, combining mouse genetics, functional genomics, molecular biology and circuit neurobiology.
The evolution of the cerebral cortex is thought to underlie the human brain’s most remarkable cognitive, perceptive, and motor capabilities. Miswiring of cortical circuitry during development can lead to disorders, including autism and schizophrenia, that affect the most distinctly human cognitive functions.
The Kwan laboratory focuses on examining the fundamental and pathogenic mechanisms that can have in vivo consequences for neural circuit development and function. They aim to understand the molecular and cellular mechanisms that underlie normal neural circuit assembly in the cerebral cortex, and the role circuit dysregulation plays in human neurodevelopmental disorders, in particular autism spectrum disorder, fragile X syndrome, and schizophrenia.
The lab’s overarching research goals are: 1) to understand the mechanisms by which neural progenitor cells give rise to diverse repertoires of cortical neuronal subtypes; and 2) to understand the mechanisms that ultimately wire cortical neurons into functional neural circuits. An integrative approach is used, combining mouse genetics, functional genomics, molecular biology and circuit neurobiology.
研究兴趣
论文共 39 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGYno. 1 (2024)
Nature Neuroscienceno. 7 (2022): 839-840
Proceedings of the National Academy of Sciences of the United States of Americano. 21 (2021)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn