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Koga’s early research focused on the studies of optically active amino acids as chiral sources for asymmetric synthesis. In particular, stereoselective hydride reduction and stereocontrolled deamination of amino acid esters were significant and versatile methods investigated by Koga for manipulating amino acid stereocenters in asymmetric synthesis. By application of these methods, a number of pharmaceutically useful chiral compounds have been synthesized from optically active amino acids, beginning with chloramphenicol in his B.S. thesis and culminating in polycyclic natural products such as maritidine, galanthamine, podorhizon, steganacin, verrucarinolactone, bourbonene, spatol and carbapenam. Further development in the chemistry of amino acids led to their use as chiral auxiliaries, particularly in asymmetric alkylation and conjugate addition at the α- or β-carbon of carbonyl compounds, exploiting chiral enamines or enimines derived from amino acid esters.
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ACS omegano. 35 (2022): 31260-31270
mag(2015)
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mag(2014)
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