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Research in the Moremen lab focuses on the biochemistry, structure, and regulation of enzymes involved in the biosynthesis, recognition, and catabolism of mammalian glycoproteins. Carbohydrate structures on glycoproteins contribute to many biological recognition events during development, oncogenic transformation, and cell adhesion. Large numbers of intracellular and extracellular proteins contain covalently bound glycans and alterations in the synthesis and degradation of these structures can occur in human genetic diseases and cancer. Many questions remain regarding the regulation of glycosylation pathways, the structures and functions of the processing enzymes, and the specificity and regulation of protein-carbohydrate interactions during development. Research in the Moremen lab is focused on developing novel strategies to address contemporary problems in the regulation, roles, mechanism, and machinery of mammalian protein glycosylation with efforts in four main areas
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Journal of the American Chemical Society (2024)
NATURE PLANTSno. 4 (2023): 673-673
bioRxiv : the preprint server for biology (2023)
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Yunfei Wu, Gael M. Vos,Chin Huang,Digantkumar Chapla, Anne L. M. Kimpel,Kelley W. Moremen,Robert P. de Vries,Geert-Jan Boons
JACS AUno. 11 (2023): 3155-3164
Journal of Biological Chemistryno. 3 (2023): 103737-S389
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Aarya Venkat, Daniel Tehrani,Rahil Taujale,Wayland Yeung,Saber Soleymani, Amitabh Priyadarshi,Krzysztof Kochut,Kelley Moremen,Natarajan Kannan
Journal of Biological Chemistryno. 3 (2023): 103746-103746
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João B. Vicente, Ana Catarina L. Guerreiro, Beatriz Felgueiras,Digantkumar Chapla, Daniel Tehrani,Kelley W. Moremen,Júlia Costa
Scientific Reportsno. 1 (2023): 1-13
ISRAEL JOURNAL OF CHEMISTRY (2023)
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Aarya Venkat, Daniel Tehrani,Rahil Taujale,Wayland Yeung,Saber Soleymani, Amitabh Priyadarshi,Krzysztof Kochut,Kelley Moremen,Natarajan Kannan
JOURNAL OF BIOLOGICAL CHEMISTRYno. 3 (2023): S393-S394
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