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Microbes must cope with harsh, rapidly changing environments to survive. To do this, microbes have developed sophisticated mechanisms to (a) sense the changes in the environment, and (b) respond quickly to these changes to protect itself from harm or capitalize on an opportunity. Our lab seeks to rewire these fundamental input/output relationships to program cells to do useful things for mankind in a paradigm called synthetic biology. Inputs: We study methods to modify existing environmental detection sensors in yeast and modify them to detect new analytes. Outputs: We investigate ways microbes modify their metabolic networks and use these modifications to increase production of a given metabolite.
Synthetic biology offers a disruptive technology that has vast potential to impact the most important facets of our lives. The way we diagnose diseases, the drugs we use, the fuels we put in our cars, the plastic that is used in our potato chip bag – we have the opportunity to improve the sustainability of our lifestyle. And by reducing costs, we can make aspects of our lifestyle available to those who could not otherwise afford it. We hope to offer technical contributions that, simply put, make the world a better place.
Synthetic biology offers a disruptive technology that has vast potential to impact the most important facets of our lives. The way we diagnose diseases, the drugs we use, the fuels we put in our cars, the plastic that is used in our potato chip bag – we have the opportunity to improve the sustainability of our lifestyle. And by reducing costs, we can make aspects of our lifestyle available to those who could not otherwise afford it. We hope to offer technical contributions that, simply put, make the world a better place.
研究兴趣
论文共 67 篇作者统计合作学者相似作者
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Bradley W Biggs,Keith E J Tyo
bioRxiv : the preprint server for biology (2023)
bioRxiv (Cold Spring Harbor Laboratory)no. 11 (2023): 3301-3311
BMC bioinformaticsno. 1 (2023): 106-15
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Nick Fackler,Björn D Heijstra,Blake J Rasor,Hunter Brown,Jacob Martin, Zhuofu Ni,Kevin M Shebek, Rick R Rosin,Séan D Simpson,Keith E Tyo,Richard J Giannone,Robert L Hettich,
Adebola Adeniran,Keith E.J. Tyo
biorxiv(2020)
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