基本信息
浏览量:7
职业迁徙
个人简介
Our group has already identified the factor Noggin, which efficiently induces differentiation of myocardial progenitors from ES cells. In addition, we have identified a factor that induces cardiomyocyte differentiation from myocardial progenitors and a factor that causes immature cardiomyocytes that have just differentiated to undergo cell division. Moreover, by identifying a dye that is capable of specifically staining cardiomyocytes and developing a technique to separate the cardiomyocytes it has become possible to efficiently transplant cardiomyocytes without forming teratomas. In this project we plan to conduct basic research and a preclinical study in order to realize "a regenerated cardiomyocyte transplantation method using human ES cells" as an alternative to replace heart transplantation as a means of treating severe heart failure in humans. More specifically, we aim to (1) establish a technique to use human ES cells to produce large numbers of cardiomyocytes, (2) separate and purify regenerated cardiomyocytes and undifferentiated stem cells/non-cardiomyocytes and establish a transplantation technique that is not associated with teratoma formation, (3) transplant human regenerated cardiomyocytes into monkey hearts free of heart disease and assess pathological changes immediately after transplantation, whether teratomas have formed, arrhythmogenicity, etc., and (4) transplant human regenerated cardiomyocytes into the hearts of monkeys with heart failure after producing a myocardial infarction, and to encompass all preclinical studies prior to clinical application.
研究兴趣
论文共 1195 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JACC: Asiano. 4 (2024): 306-319
Journal of Molecular and Cellular Cardiology (2024): 90-100
Wenqi Ma,Kangni Jia, Haomai Cheng, Hong Xu, Zhigang Li,Hang Zhang,Hongyang Xie,Lingfang Zhuang, Ziyang Wang,Yuke Cui, Hang Sun,Lei Yi,
Circulation research (2024)
Journal of cardiac failureno. 4 (2023): 503-513
crossref(2023)
EClinicalMedicine (2023): 102141
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn