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个人简介
Larry joined the National Cancer Institute in 1971, where he spent the next four decades. He began by making major contributions to the understanding of the chemistry of the carcinogenic nitrosamines. By accumulating sufficient knowledge of their fundamental physicochemical properties, his group introduced means of preventing their formation, contributed to the understanding of their metabolism and mechanisms of action and tested equipment that could analyze the environmental distribution of those carcinogens.
In 1989, recognizing exploding interest in the chemistry and pharmacology of nitric oxide (NO), he developed important chemical tools to study the chemistry and biology of the compound, contributing many landmark discoveries to the field. He is perhaps best known for the NO-releasing diazeniumdiolate reagents he developed as tools to generate NO at tunable rates in cell culture and other aqueous media.
In 1989, recognizing exploding interest in the chemistry and pharmacology of nitric oxide (NO), he developed important chemical tools to study the chemistry and biology of the compound, contributing many landmark discoveries to the field. He is perhaps best known for the NO-releasing diazeniumdiolate reagents he developed as tools to generate NO at tunable rates in cell culture and other aqueous media.
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Anna E Maciag,Ryan J Holland,Youseung Kim,Vandana Kumari, Christina E Luthers, Waheed S Sehareen,Debanjan Biswas,Nicole L Morris,Xinhua Ji,Lucy M Anderson,Joseph E Saavedra,Larry K Keefer
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