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Her research is focused on the role of NADPH oxidases (Nox) in vascular biology and disease. She has a particular interest in how reactive oxygen species (ROS) derived from these enzymes regulate the signaling pathways leading to smooth muscle proliferation, migration and differentiation. Using transgenic and knockout mouse models, her laboratory has demonstrated a role for the NADPH oxidases in hypertension, collateral formation, vessel contraction and restenosis. Ongoing research is focused on Poldip2, a p22phox binding protein that regulates Nox4 activity and plays major roles in cell cycle progression, matrix regulation and barrier function. Dr. Griendling has trained 46 post-doctoral fellows and PhD students, many of whom have successful academic careers. She is a member of the graduate faculty in Molecular and Systems Pharmacology.
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American journal of physiology. Heart and circulatory physiologyno. 2 (2023): H321-H322
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Springer eBookspp.179-214, (2023)
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David A Bulger,Kathy K Griendling
Circulation researchno. 9 (2023): 1141-1143
Reshma Jagsi, T DeLene Beeland, Kevin Sia,Lauren A Szczygiel,Matthew R Allen,Vineet M Arora,Megan Bair-Merritt,Melissa D Bauman,Hillary R Bogner,Gail Daumit,Esa Davis,Angela Fagerlin,
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