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Our overall goal is to understand how regulation of the muscular layer of blood vessels contributes to normal vessel function and to cardiovascular disease. Hyperproliferation or dysfunction in vascular smooth muscle cells contributes to atherosclerosis, hypertension, organ transplant failure, and failure of revascularization therapies such as balloon angioplasty or bypass surgery. By understanding the regulatory mechanisms of vascular smooth muscle, we aim to develop new therapies for treatment and prevention of cardiovascular diseases.
Specialized Terms: Vascular smooth muscle; Differentiation; Signal transduction; Transcription; Epigenetics
Our overall goal is to understand how regulation of the muscular layer of blood vessels contributes to normal vessel function and to cardiovascular disease. Hyperproliferation or dysfunction in vascular smooth muscle cells contributes to atherosclerosis, hypertension, organ transplant failure, and failure of revascularization therapies such as balloon angioplasty or bypass surgery. By understanding the regulatory mechanisms of vascular smooth muscle, we aim to develop new therapies for treatment and prevention of cardiovascular diseases.
Specialized Terms: Vascular smooth muscle; Differentiation; Signal transduction; Transcription; Epigenetics
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论文共 155 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Raja Chakraborty,Vincent P Schulz,Kimberly Lezon-Geyda,Jui M Dave,Kathleen A. Martin, Patrick G Gallagher
biorxiv(2024)
crossref(2024)
American journal of physiology. Heart and circulatory physiologyno. 1 (2023): H77-H88
Dennis Liang Fei,Hua Li, Courtney D. Kozul, Kendall E. Black,Samer Singh,Julie A. Gosse,James DiRenzo,Kathleen A. Martin,Baolin Wang, Joshua W. Hamilton,Margaret R. Karagas,David J. Robbins
crossref(2023)
biorxiv(2023)
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