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职业迁徙
个人简介
Research interest: Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development.
Research details
Work in my laboratory is aimed towards the understanding of molecular pathways that govern chronic kidney disease development. We have two general areas of interest: hypothesis generating (high trough-put, translational) and mechanistic studies. Over the past 10 years we banked and analyzed (combined genetic, epigenetic and genomic approaches) a large number of healthy and diseased human kidney tissue samples. We hypothesize that integrative analysis of epigenetic and genetic settings in diseased cells can provide a rational basis for more accurately modeling the critical biological pathways involved in mediating the progressive phenotype in individual patients. We also predict that epigenomic integrative analysis can be used to determine the identity of chromatin and transcription factors that contribute mechanistically to aberrant transcriptional programming in chronic kidney disease, and that this information can be used for designing therapeutic strategies. We are specifically interested in defining cis-regulatory modules (promoters, enhancers and repressors) that govern the normal and altered epithelial phenotype in diseased kidneys.
In addition, we use genetic approaches and mouse as a model organism to test the role of candidate signaling molecules and regulatory pathways directly in vivo. The Cre/loxP and tet inducible transgenic technologies allow us to analyze the function of particular factors by deleting or overexpressing genes that encode them in specific cell types in the kidney. Specifically, we are working on determining the role of the Notch and Wnt/beta-catenin pathway in chronic kidney disease development, renal epithelial cell homeostasis, renal stem or progenitor cell function and differentiation. Our recent results highlight the role of embryonic programs in adult disease development.
Rotation Projects
There are several; please speak with Dr. Susztak.
Research details
Work in my laboratory is aimed towards the understanding of molecular pathways that govern chronic kidney disease development. We have two general areas of interest: hypothesis generating (high trough-put, translational) and mechanistic studies. Over the past 10 years we banked and analyzed (combined genetic, epigenetic and genomic approaches) a large number of healthy and diseased human kidney tissue samples. We hypothesize that integrative analysis of epigenetic and genetic settings in diseased cells can provide a rational basis for more accurately modeling the critical biological pathways involved in mediating the progressive phenotype in individual patients. We also predict that epigenomic integrative analysis can be used to determine the identity of chromatin and transcription factors that contribute mechanistically to aberrant transcriptional programming in chronic kidney disease, and that this information can be used for designing therapeutic strategies. We are specifically interested in defining cis-regulatory modules (promoters, enhancers and repressors) that govern the normal and altered epithelial phenotype in diseased kidneys.
In addition, we use genetic approaches and mouse as a model organism to test the role of candidate signaling molecules and regulatory pathways directly in vivo. The Cre/loxP and tet inducible transgenic technologies allow us to analyze the function of particular factors by deleting or overexpressing genes that encode them in specific cell types in the kidney. Specifically, we are working on determining the role of the Notch and Wnt/beta-catenin pathway in chronic kidney disease development, renal epithelial cell homeostasis, renal stem or progenitor cell function and differentiation. Our recent results highlight the role of embryonic programs in adult disease development.
Rotation Projects
There are several; please speak with Dr. Susztak.
研究兴趣
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Kaishu Mason,Anuja Sathe,Paul R. Hess,Jiazhen Rong,Chi-Yun Wu,Emma Furth,Katalin Susztak, Jonathan Levinsohn,Hanlee P. Ji,Nancy Zhang
Xiujie Liang,Hongbo Liu,Hailong Hu,Jianfu Zhou,Amin Abedini, Andrea Sanchez Navarro, Konstantin A Klötzer,Katalin Susztak
bioRxiv : the preprint server for biology (2024)
Nature communicationsno. 1 (2024): 2537-2537
Amin Abedini, Jonathan L Levinsohn, Konstantin Kloetzer, Bernhard Dumoulin,Ziyuan Ma,Julia Frederick,Poonam Dhillon,Michael S. Balzer,Rojesh Shrestha,Hongbo Liu,Steven Vitale,Kishor Devalaraja-Narashimha,
biorxiv(2024)
Fibrosisno. 1 (2024): 10001-10001
Kidney International (2024)
Amin Abedini, Andrea Sanchez-Navaro,Junnan Wu, Konstantin A. Kloetzer,Ziyuan Ma,Bibek Poudel,Tomohito Doke,Michael S. Balzer,Julia Frederick,Hana Cernecka,Hongbo Liu,Xiujie Liang,
JOURNAL OF CLINICAL INVESTIGATIONno. 1 (2024)
Nature Communicationsno. 1 (2024): 1-1
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024)
Sybille Koehler, Felicitas Hengel,Bernhard Dumoulin, Laurel Damashek,Lawrence B. Holzman,Katalin Susztak,Tobias B. Huber
Kidney International (2024)
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