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Aim of our research is to elucidate the molecular mode of action of antimicrobial peptides to design novel antibiotic agents that combat bacteria which are multi-resistant to conventional antibiotics. Our knowledge is fundamentally based on understanding how these peptides discriminate between host and bacteria at which lipid composition of plasma membrane plays an essential role. Thus we have been studying the interaction of natural and synthetic antimicrobial peptides with membrane mimetic systems and cell membranes using thermodynamic, spectroscopic and structural techniques. Within the framework of an EU-project coordinated by myself a world-wide patent was granted to a family of peptides derived from lactoferrin, a protein highly concentrated in human colostrum (“first milk”).
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Ayse Oen, Djenana Vejzovic,James Jennings,Lena Parigger,Robert A. Cordfunke,Jan Wouter Drijfhout,Karl Lohner,Nermina Malanovic
ANTIBIOTICS-BASELno. 7 (2023): 1163-1163
Tim J. Bull,Tulika Munshi,Paula M. Lopez-Perez, Andy C. Tran,Catherine Cosgrove,Angela Bartolf,Melissa Menichini,Laura Rindi,Lena Parigger,Nermina Malanovic,Karl Lohner, Carl J. H. Wang,
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 24 (2023): 17555
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