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个人简介
His research program focuses on understanding how complex physiological systems such as the skeletal system establish function during growth and maintain function during aging. Having a better understanding of how complex systems work is expected to benefit efforts to reduce fracture risk by identifying the genetic and environmental factors that impair (or promote) specific components of the functional adaptation process that compromise (or improve) musculoskeletal health. A pattern in the way individuals coordinate their traits was identified in a mouse model and then successfully translated to the human skeleton. This pattern or network of trait interactions has experimental value in that genetic factors regulating each component of the network can be teased out and studied. The network also has tremendous clinical value because it means a person's fracture risk can be predicted earlier in life and will provide insight into novel prophylactic therapies. Evaluating acquired trait sets is expected to provide a more flexible, personalized approach to identifying novel biomechanical and biological pathways contributing to bone fragility.
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Current Osteoporosis Reportspp.1-1, (2023)
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Holly LoTurco, Quincy Bianchi,Ketsia Seide, Chethana Gallage-Dona,Erin Carter,Karl Jepsen,Cathleen Raggio
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 174-174
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Karl Jepsen,Erin Bigelow,Michael Casden,Robert Goulet,Kathryn Kennedy, Samantha Hertz, Chandan Kadur,Bonnie Nolan,Kerry Richards-McCullough, Steffanie Merillat,Carrie Karvonen-Gutierrez,Todd Bredbenner
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 329-329
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JOURNAL OF BONE AND MINERAL RESEARCH (2023): 322-322
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