Karl Drlica
Adjunct Professor
Department of Microbiology
Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers, The State University of New Jersey;The Public Health Research Institute, International Center for Public Health, New Jersey Medical School, Rutgers, The State University of New Jersey
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个人简介
Dr. Drlica’s work addresses the general problem of antibiotic resistance. Drlica and Dr. Xilin Zhao at PHRI formulated the mutant selection window hypothesis as a framework for understanding relationships between antimicrobial concentration and selective enrichment of mutant subpopulations. Expansion of these sub-populations is thought to lead to new resistance. The work reveals a flaw in the way antibiotics are currently dosed: in almost every case examined, drug concentrations inside patients fall within the selection window during much of the dosing interval. Thus, the emergence of resistance is inevitable when large numbers of prescriptions are filled. According to the window hypothesis, new compounds need to be designed so they can be dosed high enough to restrict resistant mutant enrichment.
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论文共 122 篇作者统计合作学者相似作者
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Somnath Shee,Samsher Singh,Ashutosh Tripathi,Chandrani Thakur,Anand T Kumar, Mayashree Das,Vikas Yadav, Sandeep Kohli,Raju S Rajmani,Nagasuma Chandra,Harinath Chakrapani,Karl Drlica,
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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Somnath Shee,Samsher Singh,Ashutosh Tripathi,Chandrani Thakur,Anand T Kumar, Mayashree Das,Vikas Yadav,Sakshi Kohli,Raju S. Rajmani,Nagasuma Chandra,Harinath Chakrapani,Karl drlica,
biorxiv(2022)
Jie Zeng,Yuzhi Hong, Ningqiu Zhao, Qianyu Liu, Weiwei Zhu,Lisheng Xiao,Weijie Wang,Miaomiao Chen,Shouqiang Hong,Liwen Wu,Yunxin Xue,Dai Wang,
Somnath Shee,Samsher Singh,Ashutosh Tripathi,Chandrani Thakur, Anand Kumar T, Mayashree Das,Vikas Yadav,Sakshi Kohli,Raju S Rajmani,Nagasuma Chandra,Harinath Chakrapani,Karl Drlica,
Joyce Sutcliffe, Robert McLaughlin,Guy Webster,Andrew F Read,Karl Drlica,Russell Elliott,Iain Stuart
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