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Research Abstract
We study the molecular mechanisms that control T cell and NK cell function in the tumor microenvironment, with a particular focus on the pathways that constrain their effector function. We also study the mechanisms that enable tumor cells to resist an attack by T cells or NK cells. Our strategy integrates investigation of the immune system in human tumors with in-depth mechanistic investigation in model systems. We embrace the complexity of the human cancers and their interaction with the immune system as an opportunity to discover novel biology that opens new perspectives for cancer treatment. Of particular interest are strategies that are relevant for multiple cancer types. We hope to inspire advances in cancer treatment that harness the power of the immune system.
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论文共 387 篇作者统计合作学者相似作者
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Michalina Janiszewska, Doris P. Tabassum,Zafira Castano,Simona Cristea,Kimiyo N. Yamamoto,Natalie L. Kingston,Katherine C. Murphy,Shaokun Shu, Nicholas W. Harper, Carlos Gil Del Alcazar,Masa Aleckovic,Muhammad B. Ekram,
NATURE CELL BIOLOGY (2024)
Francesca Alvarez Calderon,Byong H Kang,Oleksandr Kyrysyuk,Shiwei Zheng, Hao Wang, Nathan D Mathewson,Adrienne M Luoma, Xiaohan Ning,Jason Pyrdol, Xuan Cao,Mario L Suvà,Guo-Cheng Yuan,
Bloodno. 12 (2024): 1124-1138
Elisha R Verhaar, Anouk Knoflook,Novalia Pishesha,Xin Liu, Willemijn J C van Keizerswaard,Kai W Wucherpfennig,Hidde L Ploegh
Frontiers in immunology (2024): 1368586-1368586
Michalina Janiszewska, Doris P Tabassum,Zafira Castaño,Simona Cristea,Kimiyo N Yamamoto,Natalie L Kingston,Katherine C Murphy,Shaokun Shu, Nicholas W Harper, Carlos Gil Del Alcazar,Maša Alečković,Muhammad B Ekram,
Nature cell biology (2024)
Ye Zhao,Kai W Wucherpfennig
Current opinion in oncologyno. 3 (2024): 136-142
Kimberly R. Hagel,Rand Arafeh,Sydney Gang,Taylor E. Arnoff,Rebecca C. Larson,John G. Doench,Nathan D. Mathewson,Kai W. Wucherpfennig, Marcela V. Maus,William C. Hahn
crossref(2023)
crossref(2023)
MEDno. 7 (2023): 457-+
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Jiaxin Liang,Tevis Vitale, Xixi Zhang,Thomas D Jackson,Deyang Yu, Mark Jedrychowsk,Steven P Gygi,Hans R Widlund,Kai Wucherpfennig,Pere Puigserver
bioRxiv : the preprint server for biology (2023)
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