Professor Siau has more than 300 academic publications. His research publications have appeared in journals such as MIS Quarterly, Journal of the Association for Information Systems, Journal of Strategic Information Systems, Decision Support Systems, Information Systems Journal, Data and Knowledge Engineering, IEEE Transactions on Information Systems in Biomedicine, IEEE Transactions on Systems, Man, and Cybernetics, IEEE Transactions on Professional Communication, IEEE Transactions on Education, Communications of the ACM, Communications of the AIS, and others. According to Google Scholar, he has a citation count of more than 19,500. His h-index and i10-index, according to Google Scholar, are 72 and 178, respectively. Professor Siau is consistently ranked as one of the top information systems researchers globally based on his h-index and productivity rate. In 2006, he was ranked as one of the top ten e-commerce researchers globally (Arithmetic Rank of 7, Geometric Rank of 3). In 2006, the citation count for his paper "Building Customer Trust in Mobile Commerce" was ranked in the top 1% in the field, as reported by Essential Science Indicators. He is also on 2020, 2021, and 2022 Stanford University lists of the top 2% most-cited scientists in the world (he is ranked in the top 1%) and ranked as one of the top computer scientists in the U.S., China, and the world. He has been involved in projects totaling more than US $6 million, and his research has been funded by NSF, IBM, NSFC, and other business organizations.

Professor Siau has received numerous teaching, research, service, and leadership awards. He received the University of Nebraska-Lincoln Distinguished Teaching Award and the College of Business Administration Distinguished Teaching Award in 2001. He was awarded the Organizational Leadership Award in 2000 and the Outstanding Leader Award in 2004 by the Information Resources Management Association. He received the University of Nebraska-Lincoln College of Business Administration Research Award in 2005, and the Faculty External Recognition Award and Outstanding Contributions to Graduate Studies Award from the Missouri University of Science and Technology in 2020. He was a recipient of the prestigious International Federation for Information Processing (IFIP) Outstanding Service Award in 2006, IBM Faculty Awards in 2006 and 2008, IBM Faculty Innovation Award in 2010, AIS Sandra Slaughter Service Award in 2019, AIS Award for Outstanding Contribution to IS Education in 2019, and AIS Fellow Award in 2022.