My research interests centre around the development, evaluation, application and translation of (Bayesian) statistical methods in Health Technology Assessment (HTA) and Health Data Science, more specifically;
Design & analysis of clinical trials – particularly methods for dealing with treatment switching & extrapolation
Evidence synthesis – particularly methods for dealing with; heterogeneity (statistical, clinical & methodological), Indirect Comparisons (IC)/Network Meta-Analysis (NMA) & inclusion of observational/Real World Evidence (RWE)
Methods for estimating comparative effectiveness using observational/non-randomised data in HTA
Disease natural history modelling – particularly in rare and/or complex diseases (e.g. multi-morbidity)
Methods for the development of dynamic risk prediction models using linked exposure/biomarker and clinical outcome data obtained from Electronic Health Records (EHRs)