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职业迁徙
个人简介
A major interest of my research is to understand the effector immune responses that protect us against infection and cancer and how, when uncontrolled this can lead to autoimmune diseases. I am particularly interested the factors that affect the induction, of the distinct subpopulations of CD4+ T cells, termed Th1, Th2 and T regulatory (Treg) and Th17 cells, and the role of innate immune system, in particular dendritic cells, in directing T cell responses. The work has direct application to the development of new or improved vaccines and includes studies on Bordetella pertussis, Fasciola hepatica, influenza virus and hepatitis C virus. In the last number of years my group has focused on immune regulation and immune modulation by pathogens. This has been made possible through PI and Strategic research cluster (SRC) awards from Science Foundation Ireland. The aims are to examine the role of pathogen-derived molecules in modulating immune responses, with particular reference to the induction, regulation and function of T cell subtypes and the induction and control of inflammatory responses. Our hypothesis is that the study of immunomodulation by microbial pathogens is an ideal approach to understand mechanisms of protective immunity and immunoregulation in vivo and will allow the identification and characterization of novel immunomodulatory molecules with potential as therapies for immune mediated diseases. We have identified molecules capable of specifically suppressing or enhancing immune response that regulate or mediate certain human diseases. The application of this research is the development of new or improved vaccines against infectious diseases, active immunotherapeutics against cancer and anti-inflammatory therapeutics against autoimmune diseases. A recent SFI PI award on 'the role of regulatory T cell control of pathogenic and effector T cells and their manipulation as potential therapies for human disease' is focused on the interface between innate and adaptive immunity, specifically how we can manipulate dendritic cells to selectively alter the balance of regulatory (Treg) versus effector (Th1 or Th2) or pathogenic (Th17). Our aim is to design new approaches to treat autoimmunity by enhancing induction of Treg which suppress Th17 cells and to develop new infectious diseases vaccines and cancer immunotherapeutics by enhancing induction of Th1 and Th2 cells, while inhibiting Treg cells.
研究兴趣
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The Journal of infectious diseases (2024)
Parasite immunologyno. 12 (2023): e12975-e12975
Tristram A. J. Ryan,Alexander Hooftman,Aisling M. Rehill,Matt D. Johansen, Eoin C. O' Brien,Juliana E. Toller-Kawahisa,Mieszko M. Wilk,Emily A. Day,Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm,
NATURE COMMUNICATIONSno. 1 (2023)
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crossref(2023)
Current Opinion in Immunology (2023): 102355-102355
Lucy M. Curham, Jenny M. Mannion, Clíodhna M. Daly, Mieszko M. Wilk, Lisa Borkner, Stephen J. Lalor, Rachel M. McLoughlin, Kingston H.G. Mills
crossref(2023)
European Journal of Immunologyno. 5 (2023)
引用6浏览0引用
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The British journal of dermatologyno. 4 (2023): 11-12
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