Karl D. Hardman

The DuPont Merck Pharmaceutical Co. Chemical and Physical Sciences, Experimental Station, Wilmington DE 19880-0500 USA

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ChemInform Abstract: P1,P2′-Linked Macrocyclic Amine Derivatives as Matrix Metalloproteinase Inhibitors

James J.-W. Duan,Lihua Chen,Chu-Biao Xue,Zelda R. Wasserman,Karl D. Hardman,Maryanne B. Covington,Robert R. Copeland,Elizabeth C. Arner,Carl P. Decicco

Cheminform, no. 37 (2010)

Bibtex

Identification of a Selectivity Determinant for Inhibition of Tumor Necrosis Factor-α Converting Enzyme by Comparative Modeling

Zelda R Wasserman,James J.-W Duan,Matthew E Voss,Chu-Biao Xue,Robert J Cherney,David J Nelson,Karl D Hardman,Carl P Decicco

Chemistry & Biology, no. 3 (2003): 215-223

EIWOSBibtex

Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships

James J.-W. Duan,Lihua Chen,Zelda R. Wasserman,Zhonghui Lu,Rui-Qin Liu,Maryanne B. Covington,Mingxin Qian,Karl D. Hardman,Ronald L. Magolda,Robert C. Newton,David D. Christ,Ruth R. Wexler

Journal of Medicinal Chemistry, no. 23 (2002): 4954-4957

Cited by9Bibtex

P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors

J J Duan,L Chen,C B Xue,Z R Wasserman,K D Hardman,M B Covington,R R Copeland,E C Arner,C P Decicco

Bioorganic & medicinal chemistry letters, no. 10 (1999): 1453-1458

Cited by8WOSEIBibtex

Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-α production

Robert J. Cherney,Li Wang,Dayton T. Meyer,Chu-Biao Xue,Elizabeth C. Arner,Robert A. Copeland,Maryanne B. Covington,Karl D. Hardman,Zelda R. Wasserman,Bruce D. Jaffee,Carl P. Decicco

Bioorganic & Medicinal Chemistry Letters, no. 9 (1999): 1279-1284

Cited by17EIWOSBibtex

P 1 , P 2 ′-Linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors

James J W Duan,Lihua Chen,Chubiao Xue,Zelda R Wasserman,Karl D Hardman,Maryanne B Covington,Robert R Cope,Elizabeth C Arner,Carl P Decicco

Bioorganic & Medicinal Chemistry Letters, (1999)

Bibtex

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases

Irina C. Jacobson,Prabhakar G. Reddy,Zelda R. Wasserman,Karl D. Hardman,Maryanne B. Covington,Elizabeth C. Arner,Robert A. Copeland,Carl P. Decicco,Ronald L. Magolda

Bioorganic & Medicinal Chemistry Letters, no. 7 (1998): 837-842

Cited by15EIWOSBibtex

Potent carboxylate inhibitors of stromelysin containing P2′ piperazic acids and P1′ biaryl moeities

Robert J. Cherney,Carl P. Decicco,David J. Nelson,Li Wang,Dayton T. Meyer,Karl D. Hardman,Robert A. Copeland,Elizabeth C. Arner

Bioorganic & Medicinal Chemistry Letters, no. 13 (1997): 1757-1762

EIBibtex

Complementarity of Combinatorial Chemistry and Structure-Based Ligand Design: Application to the Discovery of Novel Inhibitors of Matrix Metalloproteinases

Arlene Rockwell,Mark Melden,Robert A. Copeland,Karl D Hardman,Carl P. Decicco,William F. DeGrado

Journal of The American Chemical Society, no. 42 (1996): 10337-10338

Cited by100Bibtex

Roles of the propeptide and metal ions in the folding and stability of the catalytic domain of stromelysin (matrix metalloproteinase 3)

D R Wetmore,K D Hardman

Biochemistry, no. 21 (1996): 6549-6558

Cited by31WOSBibtex

Structures of Candida albicans dihydrofolate reductase: holoenzyme and ternary inhibitor complexes

K D Hardman,Lee F Kuyper,David P Baccanari,M E Fling,Joseph H Chan,Robert L Tansik, D B Stewart,Marc D Whitlow,A J Howard

Acta Crystallographica Section A, (1996)

Bibtex

STRUCTURES OF CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE: HOLOENZYME AND TERNARY INHIBITOR COMPLEXES

Marc Whitlow,Andrew J. Howard,David Stewart,Karl D. Hardman,Lee F. Kuyper,David P. Baccanari,Mary Fling,Joseph H. Chan,Robert L. Tansik

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, no. SUPnan (1996): C208-C209

Bibtex

1.85 A structure of anti-fluorescein 4-4-20 Fab

Marc D Whitlow,Andy J Howard,J F Wood,Voss, E W,K D Hardman

Protein engineering, no. 8 (1995): 749-761

WOSBibtex

1.85 Å structure of anti-fluorescein 4-4-20 Fab

Marc Whitlow,Andrew J. Howard,Jay F. Wood,Edward W. Voss,Karl D. Hardman

Protein Engineering Design & Selection, no. 8 (1995): 749-761

Cited by64Bibtex

Probing the P3′ pocket of stromelysin with piperazic acid analogs

David A. Nugiel,Kim Jacobs,Carl P. Decicco,David J. Nelson,Robert A. Copeland,Karl D. Hardman

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, no. 24 (1995): 3053-3056

Cited by4EIBibtex

An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability

Mare Whitlow,Brian A. Bell,Sheau-Line Feng,David Filpula,Karl D. Hardman,Steven L. Hubert,Michele L. Rollence,James F. Wood,Margaret E. Schott,Diane E. Milenic,Takashi Yokota,Jeffrey Schlom

Protein engineering, no. 8 (1993): 989-995

Cited by212WOSBibtex

1.67-A X-ray structure of the B2 immunoglobulin-binding domain of streptococcal protein G and comparison to the NMR structure of the B1 domain

A Achari,S P Hale,A J Howard,G M Clore,A M Gronenborn,K D Hardman,M Whitlow

Biochemistry, no. 43 (1992): 10449-10457

Cited by121WOSBibtex

New concepts in monoclonal antibody based radioimmunodiagnosis and radioimmunotherapy of carcinoma

J Schlom,D E Milenic,M Roselli,D Colcher,R Bird,S Johnson,K D Hardman,F Guadagni,J W Greiner

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Bi..., no. 4 (1991): 425-435

Cited by24WOSEIBibtex

Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli

M W Pantoliano,R E Bird,S Johnson,E D Asel,S W Dodd,J F Wood,K D Hardman

Biochemistry, no. 42 (1991): 10117-10125

Cited by129WOSBibtex

Molecular modelling of protein-carbohydrate interactions. Docking of monosaccharides in the binding site of concanavalin A

A Imberty,K D Hardman,J P Carver,S Pérez

Glycobiology, no. 6 (1991): 631-642

Cited by93WOSBibtex

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