基本信息
浏览量:1655
职业迁徙
个人简介
My laboratory studies the structural and functional basis of receptor/ligand interactions in systems which are relevant to human health and disease. Our investigations are aimed at understanding the molecular recognition properties governing the interactions of receptors with their ligands, and the subsequent molecular events which couple ligand recognition to receptor activation. Many of the systems we are studying in the laboratory are related to the interaction of the host with the environment. The structural studies are complemented by functional approaches using molecular biology and protein engineering to dissect the structural information, design new or altered proteins with modified specificities and activities, and ultimately contribute to the development of proteins or molecules with therapeutic potential. Molecules currently under study include receptors of the immune system involved in autoimmune disorders (T cell receptors, co-receptors, MHC, cytokines), proteins involved in host-pathogen interactions and molecular mimicry (CMV and Toxoplasma surface antigens), proteins of nervous system (peptide hormone receptors, neural guidance proteins), and membrane proteins (chemokine receptors). An emerging focus of our research is to develop. using combinatorial biology approaches, novel ligands for receptors, which may have altered activities, that may serve as therapeutic starting points.
研究兴趣
论文共 399 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Hunter A. Martinez,Ievgen Koliesnik,Gernot Kaber, Jacqueline K. Reid,Nadine Nagy,Graham Barlow,Ben A. Falk,Carlos O. Medina,Aviv Hargil, Svenja Zihsler,Israel Vlodavsky,Jin-Ping Li,
Nature Communicationsno. 1 (2024): 1-15
Nathanael A. Caveney, Grayson E. Rodriguez,Christoph Pollmann, Thomas Meyer, Marta T. Borowska,Steven C. Wilson, Nan Wang,Xinyu Xiang, Karsten D. Householder, Pingdong Tao,Leon L. Su,Robert A. Saxton,
Molecular Cell (2024)
Haotian Du, Jingjia Liu,Kevin M Jude,Xinbo Yang,Ying Li, Braxton Bell, Hongli Yang, Audrey Kassardjian, Ali Mobedi,Udit Parekh, R Andres Parra Sperberg, Jean-Philippe Julien,
bioRxiv : the preprint server for biology (2024)
CELLno. 19 (2023): 4189-+
Cell reportsno. 6 (2023): 112657-112657
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Nature Biomedical Engineeringpp.1-14, (2023)
Robert A Saxton,Nathanael A Caveney,Maria Dolores Moya-Garzon, Karsten D Householder, Grayson E Rodriguez,Kylie A Burdsall,Jonathan Z Long,K Christopher Garcia
Nature communicationsno. 1 (2023): 1797-1797
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn